Serotonina,depresja, medytacja, ćwiczenia fizyczne ....
Trochę nieuporządkowanych materiałów pod rozwagę.

1. Wstęp (powiązanie stanu fizycznego z psychicznym, Papirus Edwina Smitha, fluidy Hipokratesa)

2. Historia

Odkrycie pierwszego neuroprzekaźnika

Tafil- Klawe M., Wykłady z fizjologii człowieka, Wydawnictwo Lekarskie PZWL, Warszawa 2009, str.43-44.
Odkrycie serotoniny

Thomas A. Ban, The neurotransmitter era in neuropsychofarmacology,International College of Neuropsychofarmacology, Scotland, 2010.
The Discovery of Serotonin and its Role in Neuroscience, Patricia Mack Whitaker-Azmitia, Neuropsychopharmacology (1999) 21, 2S–8S.

3. Neurofizjologiczny model działania neuroprzekaźników

Tafil- Klawe M., Wykłady z fizjologii człowieka, Wydawnictwo Lekarskie PZWL, Warszawa 2009, str.1-65.
Sadowski B., Biologiczne mechanizmy zachowania się ludzi i zwierząt, Wydawnictwo Naukowe PWN, Warszawa 2009, str. 113-134.
4. Neurofizjologiczna charakterystyka serotoniny

Sadowski B., Biologiczne mechanizmy zachowania się ludzi i zwierząt, Wydawnictwo Naukowe PWN, Warszawa 2009, str. 134-136.
Narkiewicz O., Moryś J., Neuroanatomia czynnościowa i kliniczna, Wydawnictwo Lekarskie PZWL, Warszawa 2003, str. 338-441.
5. Klasyczne połączenie serotoniny z nastrojem

Poziom serotoniny a samopoczucie

Heitzman J., Psychiatria, Wydawnictwo Lekarskie PZWL, Warszawa 2007, str. 205-206.
Monoaminergiczna teoria depresji

Sadowski B., Biologiczne mechanizmy zachowania się ludzi i zwierząt, Wydawnictwo Naukowe PWN, Warszawa 2009, str. 399-403.
The Neurobiology of Depression - Revisiting the Serotonin Hypothesis. II. Genetic, epigenetic, and clinical studies [2013]

Stressful life events and the serotonin transporter gene (5-HTT) in recurrent clinical depression [2012]

Genetyczny model nieprawidłowości w systemie serotoninergicznym u samobójców

The neuroscience of suicidal behaviors: what can we expect from endophenotype strategies? [2011]

Suicidality and Risk of Suicide [2010]

6. Poziom serotoniny a zachowania socjalne

Mice Genetically Depleted of Brain Serotonin Display Social Impairments, Communication Deficits and Repetitive Behaviors: Possible Relevance to Autism [2012]

Serotonin Selectively Modulates Reward Value in Human Decision-Making [2012]

An fMRI Study on the Role of Serotonin in Reactive Aggression [2011]

Fetal, Maternal and Placental Sources of Serotonin and New Implications for Developmental Programming of the Brain [2011]

Reconciling the Role of Serotonin in Behavioral Inhibition and Aversion: Acute Tryptophan Depletion Abolishes Punishment-Induced Inhibition in Humans [2009]

Serotonergic intervention affects both social dominance and affiliative behavior [2002]

The effect of tryptophan on social interaction in everyday life: a placebo- controlled study [2001]

7. Wpływ ćwiczeń fizycznych na uwalnianie serotoniny

Podczas wykonywania dobrowolnych rytmicznych ruchów
Ventral prefrontal cortex and serotonergic system activation during pedaling exercise induces negative mood improvement and increased alpha band in EEG [2010]

Ilchi Lee, Brain Wave Vibration, BEST life media, Sedona 2009.

Prolonged rhythmic gum chewing suppresses nociceptive response via serotonergic descending inhibitory pathway in humans [2005]

Podczas kontroli oddychania w medytacji Zen

Activation of the anterior prefrontal cortex and serotonergic system is associated with improvements in mood and EEG changes induced by Zen meditation
practice in novices [2011]

Podczas masażu

Corisol decreases and serotonin and dopamine increase following massage therapy [2005]

Cognitive Processing Volume 11, Issue 1, February 2010
Special Issue: Neuroscience of Meditation and Consciousness guest-edited by Antonino Raffone & Narayanan Srinivasan

Transcendental Meditation resets brain

Many people learn to meditate in order to relax and reduce stress, but few realise just how meditation produces these benefits. Often its effects on the mind and body are seen as no different to that of taking a short nap or practising deep breathing.
However, a new study on the effects of Transcendental Meditation, published in the US journal, Cognitive Processing, has added to the considerable body of research indicating that individuals practising the technique experience “restful alertness” — a special state of deep relaxation, quite distinct from ordinary relaxation and sleep.

Serotonin Dojo

The research study was conducted by Arita Hideho, a world-renowned authority in neurotransmitter research who is also a professor of integrated physiology at the Medical School of Toho University. Serotonin, the primary neurotransmitter Prof. Hideo studies, is a chemical messenger associated with peaceful, attentive states of being. People with depression usually have lower than normal serotonin levels. The hormone also helps to regulate sleep and reduces pain in the body. In other words, the more serotonin secreted in your brain, the happier you are.

To study the effects of Brain Wave Vibration on serotonin production, Prof. Hideo had a group of people practice Brain Wave Vibration for 15 minutes on three separate occasions. He found that the group had an average serotonin level of 186 before the training. Immediately after experiencing Brain Wave Vibration, the subjects’ levels increased to an average of 210. These effects were shown to remain relatively stable, as the average serotonin level one hour after training averaged 200.

The study also showed an increase in alpha wave production, the brain-wave state associated with waking relaxation and greater blood flow in the brain, especially in the prefrontal cortex. According to Prof. Hideo, who presented the results of the study at the Second International Brain Education and Brain Wave Vibration Seminar in November 2008, these are the most impressive results he has seen among the various mind-body training methods he has studied.

__These results are so impressive and the technique is so simple, it really makes one wonder why someone didn’t think of Brain Wave Vibration before now.

Lectures on SEROTONIN ChairpersonHideho ARITA
13:00-13:40 < Educational Lecture >
Serotonin-deficient Brain as a Mechanism of Depressive Disorder and Rhythmic Motor Exercises Hideho ARITA, Department of Physiology, Toho University School of Medicine

13:40-14:05 The Effects of Sound on the Mind and the Body from the Perspective of Serotonin Neurons Keiichiro KITA1, Yasuharu NAKAMURA 2
1 The Society for Sound Healing
2 Professor Emeritus, Showa University

14:05-14:30 Enhancing Serotonergic Activity and School-life through Tapping Touch, Koichi SARASHINA Jiyu-Gakuen Academy

(J. Intl. Soc. life Info. Sci. Vol.30, No.1, p.114)

Spontaneous Happiness and the Power of Sound Considered in Relation to the Serotonin Neuron
Keiichiro KITA1 and Hideho ARITA 2
1 The Society for Sound Healing

2 Department of Physiology, Toho University Scholl of Medicine
Depression is a disease that has spread throughout modern society (a 2008 survey reported that approximately 120 million people worldwide suffer from depression). Persons with the disease are prone to feelings of anxiety. One cause of depression is thought to be an insufficient amount of serotonin in the body. We measured the concentration of serotonin in the blood before, immediately after, and 30 minutes after application of sonic vibration energy to determine if a change in serotonin concentration occurred. Results showed a change in the concentration of serotonin in the blood: average values (n7) were 200.01ng/mL before, 191.13ng/mL immediately after, and 204.47ng/mL 30 minutes after application of sonic vibration energy. In contrast to the view of modern humans that they become happy as a result of acquiring things that exist outside of themselves, our experiment results suggest the unexplored possibility that sonic vibration may be useful as a method of producing spontaneous happiness from within.

(J. Intl. Soc. life Info. Sci. Vol.28, No.1, p.162)

Physiology of Serotonin Neurons in the Brainstem
Hideho ARITA
Department of Physiology, Toho University School of Medicine (Tokyo, Japan)
The specific functions of serotonin neurons are: (1) maintaining a clear arousal level (an effect on the cerebral cortex); (2) producing a standby status under sympathetic nerve dominance; (3) facilitating antigravity muscles; (4) producing an analgesic effect; and (5) keeping mentally calm. The activity of serotonin neurons is related to the arousal state because continuous activity is present during waking. Factors that enhance the activity of serotonin neurons during waking are the rhythmic motor exercises of respiration and walking. We have demonstrated with experimental data that Zen mediation, yoga, and tai chi exercises are effective for
activating serotonin neurons.